San Francisco is a bustling hub of business and tourism, which means traffic can sometimes be a challenge. To avoid the rush, try to steer clear of the rental center during peak hours, typically between 7 and 9 am and 4.30 and 6.30 pm.Certain roads, including Interstates 80, 180, and 238, can be particularly busy. But don't worry, with a GPS add-on to your San Francisco airport car rental, you'll be navigating the city like a local in no time.