Chicago to Indianapolis
One-Way rentals
Chicago to Indianapolis

One-Way Car Rental Chicago to Indianapolis

Explore the Midwest with a one-way car rental from Chicago. Our one-way car rentals are an easy way to get from one city to another easily and at an affordable rate. This flexible option allows you to pick up a car from one SIXT station and return it to another with no hassle. Our one-way rental deals* are available for your relocation, road trip, work trip, or if you need a car for a part of your journey. Choose from one of our premium vehicles and our array of add-ons for your next trip from Chicago to Indianapolis.

One-way Convertible Rental

One-way SUV Rental

One-way Luxury Car Rental

Drive a One-Way Car Rental from Chicago to Indianapolis

During the 3-hour drive from Chicago to Indianapolis you will see farmland and small cities. It is an easy drive on Interstate 65 starting at Gary, Indiana, and you can stop halfway in Lafayette. And you will find plenty to do in both Chicago and Indianapolis. In the winter, the weather can be unpredictable with very cold weather, snow and ice. Consider renting a vehicle with 4-wheel-drive or all-wheel-drive to make sure you get to Indianapolis safely. Choose from our selection of compact cars and sedans, sports cars, convertibles, and SUVs for your trip. Please be advised that not all vehicles are available for one-way rentals.

Driving Directions from Chicago to Indianapolis

After picking up your car rental from our Chicago O’Hare International Airport station, take Interstate 190 E from Mannheim Road. Then take the exit for I-294 S and I-65 S for 200 miles until you reach Indianapolis. We have two locations here, at the Indianapolis International Airport and in the suburb of Carmel just north of the city. You will pass through the southern suburbs of Chicago and then some farmland before hitting Lafayette, Indiana. From there, it is a short distance to Indianapolis. There are several options of places to stop for food and gas along the way. Also, please be aware that some of the roads along the route have tolls.

Driving Directions from Chicago to Indianapolis
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Sights to see on the way

Sights to see on the way

  • Michael Jackson House, Gary, IN: See the house where the famous singer grew up. 
  • Indiana Dunes National Lakeshore: Take a quick detour to stand on the shores of Lake Michigan. 
  • Prophetstown State Park, Lafayette, IN: Go for a hike or see the working farm. 
  • Tippecanoe Battlefield Museum, Battle Ground, IN: The site of the historic battle of Tippecanoe. 
  • Indianapolis Motor Speedway: Home to the Indy 500 auto race and a museum.

* SIXT one-way car rentals is subject to availability at participating SIXT locations in the US. This offer is subject to change without notice and all rentals are subject to SIXT standard terms and conditions. For the complete allowances with your rental car, please reference the rental services information.