Car rental in Panama is made easy when you choose SIXT. We offer plenty of locations in Panama including those in urban centers like Panama City, and at major airports. Our branches offer convenient hours, with some locations offering 24-hour service. You can choose from a vast range of car categories and find something to meet your needs. Our branch staff also speaks English to better assist you with your rental. If you have bulky items to haul on your trip, choose a pickup truck. Or if you are traveling with a group, book a roomy passenger van.